biorxiv.org

Virus being experimented on in China. https://www.researchgate.net/publication/377199018_Lethal_Infection_of_Human_ACE2-Transgenic_Mice_Caused_by_SARS-CoV-2-related_Pangolin_Coronavirus_GX_P2Vshort_3UTR https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf https://www.theepochtimes.com/health/chinese-scientists-reveal-experiments-with-virus-100-percent-fatal-to-mice-5560854?utm_source=atcn&utm_content=hw1016multicomp&utm_medium=email&utm_campaign=atc&utm_term=hws1comp SARS-CoV-2-related pangolin coronavirus GX_P2V, can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. Paper Authors Beijing Advanced Innovation Center Beijing University of Chemical Technology, The Fifth Medical Center of PLA General Hospital, Beijing, China. Medical School, Nanjing University, China (including a doctor trained by the Chinese military, Yigang Tong) Purpose of study Assessed virus pathogenicity Risk 100% IFR underscores a spillover risk of GX_P2V into humans, and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses. Details GX_P2V isolate was actually a cell culture-adapted mutant In this study, we cloned this mutant This is not a wild type virus It is possible that GX_P2V C7 has undergone a virulence-enhancing mutation. GX_P2V is capable of rapid mutation rates. High viral loads detected in both lung and brain tissues. Surprisingly, all the mice that were infected with the live virus succumbed to the infection within 7-8 days post-inoculation, Resulted in 100% mortality in the hACE2 mice. Clinical features Weight loss, Piloerection, hunched posture, sluggish movements, and their eyes turned white. Significant amounts of viral RNA in the brain, lung, turbinate, eye, trachea, reducing with time Infection did not lead to significant inflammatory reactions or cytokine storm Brain with high viral counts increasing during infection ACE2 receptors are found in the human brain Brainstem (especially areas regulating breathing and cardiovascular control) Hypothalamus Substantia nigra Cortex (low levels) Endothelial cells lining cerebral blood vessels Some neurons and glial cells The choroid plexus Justin Kinney, associate professor, Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, U.S. “I am especially concerned that the paper does not say what biosafety level the work was performed at. Coronavirus research in China is often done at a biosafety level (BSL-2) that is inadequate for working with potential pandemic pathogens that might be transmitted by air. “Indeed, coronavirus research done at BSL-2 may have caused the COVID-19 pandemic. And by showing that the coronavirus has a surprisingly high pathogenicity, the work underscores the need for extreme caution when working with novel coronaviruses.” Justin Goodman, senior vice president of the White Coat Waste Project, a U.S. nonprofit China-based scientists have been conducting “dangerous and deadly tests on mice.” “This is why shipping U.S. tax dollars to foreign adversaries’ unaccountable animal labs is a recipe for disaster ……