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Join Thrive Market Today to get 30% Off Your First Order AND a Free Gift Worth up to $60! http://ThriveMarket.com/ThomasDeLauer Get 10% off Troscriptions Using Code TD10: https://troscriptions.com/pages/affiliate/tom?utm_source=podcast&utm_medium=affiliate&utm_campaign=Tom Follow Dr. Sherr on Instagram: https://www.instagram.com/drscottsherr/ Dr. Sherr's Integrative Hyperbaric Practice: https://onebasehealth.com/ This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Click HERE to Subscribe: https://www.youtube.com/c/ThomasDeLauerOfficial?sub_confirmation=1 Please check out the new Shorts channel, DeLauer Clips and Workouts, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer Timestamps ⏱ 0:00 - Intro 0:10 - How Nicotine Works 2:43 - The Vagus Nerve Connection - Why Nicotine Stimulates Your Brain but Calms Your Body 3:35 - Nicotine as an Anti-Inflammatory 4:01 - Cognitive Benefits - Memory, Focus, Recall & Verbal Fluidity 4:30 - 30% Off Your First Order AND a Free Gift Worth up to $60! 4:59 - The Problem with High-Dose Nicotine Pouches 6:08 - How Delivery Method Affects Addictive Potential 6:46 - The 5mg per day Threshold for Tolerance & Addiction Risk 7:58 - Does Nicotine Cause a Crash? 9:55 - Performance-Enhancing vs Health-Optimization Nootropics 11:28 - Why Your Mitochondria Determine How Well Any Nootropic Works 13:09 - Why Nicotine's Crash Profile Is Different from Caffeine 13:35 - Chronic Inflammation & Nicotine 14:59 - Feeling Great for Days After One Dose? 15:09 - Nicotine's Immunomodulatory Effects 16:09 - Amyloid Plaques, Alzheimer's & the Immune Hypothesis 16:56 - How Nicotine Recalibrates Immune Response in the Brain 17:33 - Leaky Gut, Leaky Brain & Blood-Brain Barrier 18:35 - Lost Smell Restored by Nicotine's Anti-Inflammatory Effect 19:20 - How to Optimize Nicotine Use 19:45 - Stacking Nicotine with Alpha-GPC & L-Tyrosine 20:27 - Cellular Optimization - Glutathione, Alpha Lipoic Acid & Melatonin 21:20 - Low-Dose Nicotine & HRV Improvements 22:08 - Combining Nicotine with Methylene Blue 22:49 - How Methylene Blue Boosts Dopamine, Norepinephrine & Serotonin 23:13 - The Nicotine + Caffeine + Methylene Blue Stack 24:36 - Methylene Blue Dosing & Quality Sourcing 26:12 - Minimum Effective Dose for Nicotine 26:56 - How to Find Your Dose & Source Clean Nicotine 27:40 - Where to Find More of Dr. Sherr