Oh!Mg Relax & Dream Repair Evening Magnesium

Dr. Mikhail Kolonin, Director of the Center for Metabolic and Degenerative Diseases at UTHealth Houston, explains how GLP-1 agonists work beyond weight loss, covering appetite regulation, insulin signaling, inflammation, and direct effects on the immune system and fat tissue. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg *NMN Bio* (15% off: MODERN) https://tidd.ly/46llBuJ Magnesium, https://tidd.ly/45HEIiw NMN These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ GLP-1 drugs like semaglutide and dulaglutide have become household names for weight loss but the mechanisms driving their benefits go far deeper than appetite suppression. In this episode, Dr. Mikhail Kolonin, Professor and Director of the Center for Metabolic and Degenerative Diseases at UTHealth Houston's McGovern Medical School, breaks down how these drugs work at a mechanistic level. We cover how GLP-1 acts on the brain, gut and vasculature, why the natural hormone differs so dramatically from the drug versions, what oral GLP-1s mean for the future, and which benefits come from weight loss itself versus direct drug action. Dr. Kolonin's lab has identified IL-6 signaling in the immune system as one mechanism triggered acutely by GLP-1s, independent of obesity reversal, an early signal of where this research is heading. 📚 Chapters 0:00 How GLP-1 drugs suppress appetite and regulate glucose 3:35 Where GLP-1 is produced naturally and what triggers it 5:28 Natural hormone vs. injectable drug; what's the difference? 6:50 The coming revolution of oral GLP-1s 8:41 Pleiotropic effects; metabolic, cardiovascular and immune 🌐Links in this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9 #GLP1 #Longevity #Semaglutide