Wellness Extract

Longevity researcher Nir Barzilai on what centenarians reveal about aging and the four drugs scientists believe may target it directly. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg *NMN Bio* (15% off: MODERN) https://tidd.ly/46llBuJ Magnesium, https://tidd.ly/45HEIiw NMN These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Dr Nir Barzilai has spent decades studying people who live to 100 and beyond. What he's found challenges many assumptions about aging, disease, and what we can actually do about them. In this conversation we cover what centenarian research really shows, including why they get the same diseases as the rest of us, just decades later, and what that means for the goal of longevity medicine. We then move into the practical territory: what criteria distinguish a drug that treats one disease from one that may target aging itself, which four currently approved drugs score highest on that framework, and how leading longevity physicians are beginning to use them in practice. We also discuss GLP-1 agonists in depth; their mechanisms, the emerging evidence for benefits well beyond weight loss, and the important caveats around muscle loss. Essential viewing for anyone following the science of healthy aging. 📚 Chapters 0:00 How centenarians age; compression of morbidity explained 6:31 What centenarian research really teaches us about aging 9:40 Genetics vs environment; how much control do we have? 15:52 Longevity genes, IGF-1, and the ceiling on human lifespan 26:39 Using mRNA to replicate longevity gene effects 29:30 What makes a true gerotherapeutic drug? 35:24 The four drugs that score highest and off-label use 38:27 Secondary prevention when lifestyle alone isn't enough 42:16 Biomarkers, combination therapy and the road ahead 48:47 GLP-1 agonists mechanism, benefits and risks 57:23 Where to follow Nir's work 🌐Links in this video Dr Barzilai at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/484/nir-barzilai Healthy Longevity Medicine Society https://hlms.co/ American Federation for Aging Research https://www.afar.org/ Academy for Health & Lifespan Research https://www.ahlresearch.org/ #longevity #HealthyAging #Geroprotection