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Dr. Mikhail Kolonin reveals that GLP-1 drugs cause greater muscle loss than caloric restriction alone, driven by IL-6 signaling in skeletal muscle and discusses what can be done about it, including diet, exercise and potential pharmacological solutions.. Some links are affiliate links so we will earn a commission when they are used to purchase products. If you would like to support our channel please consider joining our Patreon https://patreon.com/ModernHealthspan ~~~~~~~~~~~~~~ *Renue By Science* (10% off: MHS) https://tinyurl.com/bdew4bfs NMN Powder • Lipo NR *BiOptimizers* (15% off: MHBIO) https://bit.ly/47VAa8f - Magnesium Breakthrough, Gluten Guardian *Seeking Health* (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO *Stemregen* (15% off: MODERN) *US only* https://tinyurl.com/45z968yr *MitoQ* https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x *Wellness Extract* (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE Geranylgeraniol • Vit E *n1o1* (10% off: Modern) https://tidd.ly/3IczGRW - Nitric Oxide Lozenges *AX3 Life* (20% off: MODERN20) https://tinyurl.com/2t3w26nw - Astaxanthin *Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder *Oxford Healthspan* (15% off: MHS) https://tinyurl.com/hrxfnzpn - Spermidine *ProHealth* (15% off: MODERN) https://prohealth.pxf.io/aObQRR NMNH 500mg These are affiliate links - using them supports the channel at no extra cost to you. ~~~~~~~~~~~~~~ Muscle loss is one of the most serious concerns with GLP-1 drugs and Dr. Mikhail Kolonin's research suggests it's more significant than the pharmaceutical industry acknowledges. In this episode he explains why lean mass loss on GLP-1s appears consistently higher than with caloric restriction alone, what his lab's genomic analysis of skeletal muscle reveals about the mechanism, and why IL-6, the same molecule that does beneficial things in fat tissue, becomes a damaging catabolic signal in muscle. He covers the clinical implications for elderly patients, the cycling problem where fat returns but muscle doesn't, and why people taking GLP-1s off-label without excess weight should be especially cautious. Crucially he also discusses what can actually be done: high protein intake, resistance exercise, and emerging pharmacological approaches including myostatin inhibition and IL-6 receptor blockade that may help preserve muscle mass during treatment. 📚 Chapters 0:00 Is muscle loss on GLP-1s a real concern? 1:51 Sarcopenic obesity; why elderly patients face the highest risk 3:50 Beyond caloric restriction; evidence of direct muscle wasting 6:00 IL-6: the same molecule, opposite effects in muscle vs fat 8:52 Can diet and exercise protect your muscle? 11:24 Pharmacological approaches; myostatin and IL-6 receptor blockade 🌐Links in this video Dr Kolonin's page https://gsbs.uth.edu/directory/profile?id=b816c8de-c9b0-40f0-873c-42fa69db82e9 #glp1 #Longevity #Telomerase